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Pyridostigmine is used for the treatment of myasthenia gravis. In patients who suffer from myasthenia gravis the muscles quickly become tired and weak and, in severe cases, the muscles may become paralysed. Myasthenia gravis is caused by excessive activity in the body of a protein called cholinesterase. Pyridostigmine belongs to a group of medicines known as cholinesterase inhibitors. Cholinesterase inhibitors stop the excessive activity of cholinesterase and in this way help muscles to work properly. Pyridostigmine is also used to treat some rare forms of constipation (paralytic ileus) and inability to pass urine after an operation.

Other names for this medication:
Pyridostigmine, Mestinon, Becilan, Distinon, Piridostigmina, Regonol,

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Pyridostigmine comes as a regular tablet, an extended-release (long-acting) tablet, and a syrup to take by mouth. It usually is taken once, twice, or several times a day, depending on the type of tablet. Your doctor may change your dose, depending on how you respond to the drug. When you first start taking pyridostigmine, your doctor may want you to keep a daily record of the time you take each dose, how long you feel better after taking each dose, and if you have side effects. This record will help the doctor decide how much drug is best for you. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pyridostigmine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the extended-release tablets whole; do not chew or crush them.

Continue to take pyridostigmine even if you feel well. Do not stop taking pyridostigmine without talking to your doctor.

Pyridostigmine overdose can cause severe illness, including muscle weakness. It is very hard to tell the difference between too little and too much pyridostigmine. Call your doctor immediately if your symptoms become worse.

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